Mauricio Laerte Silva
Hospital Infantil Joana de Gusmão-Florianópois, Brazil
Title: Assessment of subclinical cardiovascular risk factors in children and adolescents with celiac disease under treatment
Biography
Biography: Mauricio Laerte Silva
Abstract
Celiac disease (CD) is a chronic condition, which lasts for life and involves a broad spectrum of symptoms and constant dietary treatment. The impact of a gluten-free diet on nutritional and other biochemical and subclinical parameters have been systematically investigated, but further studies are still needed. We conducted an observational, cross-sectional, prospective study,with availability and not probabilistic samples, matched for sex, age and nutritional status, compounded of 30 participants with CD and 30 normal subjects. The study met all ethical principles. Total cholesterol and the LDL-C were higher in the CD group (p=0.0268 and 0.0253 respectively); the HDL-C was low in both groups; the increased intima-media thickness of the right carotid was more frequent in participants with CD (p=0.0049); and indicators of ventricular functions did not show specific changes. Therefore, patients with CD, under a gluten-free diet for at least one year, have dyslipidemia, a cardiovascular risk factor, and increased c-IMT, indicative of subclinical atherosclerosis.