Zeinab Salah Seliem
Cairo University Children Hospital, Egypt
Title: Early identification of subtle left ventricular dysfunction among asymptomatic survivors of childhood acute myeloid leukemia: Insights from the novel three dimensional speckle tracking echocardiography
Biography
Biography: Zeinab Salah Seliem
Abstract
Aim: To assess the value of novel three dimensional (3D) echocardiography and 3D speckle tracking echocardiography (3D-STE) for early detection of subtle LV myocardial dysfunction in asymptomatic survivors of childhood myeloid leukemia after anthracycline therapy.
Methods: Thirty five survivors of childhood acute myeloid leukemia (mean age 13.5±4.4 years) treated with anthracycline and 23 age-matched controls were studied. The mean period of follow up after anthracylines therapy was 2.3±1.5 years. All patients and control underwent 3D echocardiography and 3D-STE to assess global longitudinal (GLS), circumferential (GCS) and area strain (GAS).
Result: Compared to controls, patients had reduced GLS (16±3.11 vs. 18.30±2.38%, p=0.006), and area strain (24.29±4.12 vs. 26.78±2.64 0.015, p=0.015). No significant statistical difference was found between patients and control regarding GCS.
Conclusions: 3D-STE enables assessment of the deleterious effect of anthracyclines on the longitudinal myocardial deformation thus providing a novel tool for early detection of subtle LV dysfunction in childhood myeloid leukemia survivors.