Pediatric Cardiology & Healthcare

Biography

Biography: Schusterová Ingrid

Abstract

Background: Obesity is global health problem. More studies confirmed that chronic low-grade inflammation is a characteristic for obese state. The role of adenovirus 36 (Ad-36), the most widely studied infectious agent in animals and humans is because of its association with obesity. Experimental animal studies have been clearly demonstrated the association between Ad36 and obesity, but human studies results are not yet been clarified. Aim: The aim of our study is to assess the association between Ad36 and obesity in high-school students in Kosice, region Eastern Slovakia. Methods: In prospective studies, in 224 healthy students, anthropometric parameters, waist circumference (WC), fasting plasma glucose and insulin, lipids, uric acid (UA) and hepatic enzymes were measured. Ad36 antibody was detected by ELISA test. Subsequently, we analyzed the relationship between obesity, lipid and glucose profile, including insulin resistance. Results: Prevalence of obesity in Ad36 positive study group was 20%. No statistical difference was found in prevalence of obesity between Ad36 positive and Ad36 negative study groups (p=0.92). No significant association was found between insulin resistance and Ad36 positivity. Prevalence of Ad36 positivity was significantly higher (p<0.01) in boys (36.9%) to compare the girls (18.1%), Ad36 positive boys were significantly higher. Ad36 positive adolescents with normal body weight had significantly increase body height (p<0.05) and body weight (p<0.05). Ad36 positive high- school students with normal weight had higher concentration of UA. Conclusion: In our study we did not confirm a clear association of Ad36 and obesity and lipids. But we found as a first the relationship of Ad-36 and hyper-uricemia in normal weight children. Further studies with a larger demographic amount of patients and other age categories are required to elucidate this biological mechanism of such complex relationship.